The discovery of free radical-induced modifications of biomolecules (i.e 5’,8-purine cyclonucleosides and trans membrane lipids) as products of stress in cells and organisms led to their application for monitoring free radical stress under exposure to various environmental and nutritional conditions. We study the effects of radiations, drugs, oxidative and nutritional conditions characterizing the extent of damages to the DNA and membrane lipid compartments. We can evaluate the influence of neurodegenerative and tumoral conditions, bringing parallel observation of membrane lipid and DNA damages for the first time. In humans, the studies in membrane lipidomics allowed to develop a new nutri-lipidomic approach for health and prevention. In veterinary, we developed the first benchmark for the red blood cell membrane analysis in order to characterize healthy dogs and discover unbalances in animal health. The expertise in liposomes is successfully applied for the creation of innovative formulations in diagnostics, drug delivery and cosmetics.