Tedesco Daniele

Position: 
Researcher
e-mail: 
Office telephone : 
+39 051 6398308
Building: 
Isof 12
Floor: 
1
Office number: 
322
Research Unit: 
ChemNanoCare
Group: 
Researchers
Biography: 

I was born in 1984; I earned a Master's Degree in Pharmaceutical Chemistry and Technology in 2009 and a Ph.D. in Chemistry (Pharmaceutical Sciences curriculum) in 2014, both at the Alma Mater Studiorum - University of Bologna. From 2014 to 2019, I was a post-doctoral fellow at the Department of Pharmacy and Biotechnology at the Alma Mater Studiorum - University of Bologna; in 2019, I started working as a researcher at the Institute for Organic Synthesis and Photoreactivity of the Italian National Research Council (ISOF-CNR) in Bologna. My research activity is focused on the structural and stereochemical characterization of biologically active molecules and the study of molecular recognition phenomena (drug-protein, drug-DNA, protein-protein) by application of spectroscopic (mainly circular dichroism), chromatographic (enantioselective and affinity-based) and computational (TD-DFT calculations) methods. I am the author of 25 publications on international peer-reviewed journals (1 as corresponding author, 8 as first author; h-index: 9), as well as 14 oral (5 of which invited lectures or seminars) and 13 poster communications. I spent some periods abroad as visiting student or visiting scientist at King's College London (UK; 2007-2008, 7 months), at the University of Leipzig (Germany; 2012-2013, 6 months) and the Medical University of Lublin (Poland; 2016-2019, 3 months total).

Publications: 

25. De Simone A, Naldi M, Tedesco D, Bartolini M, Davani L, Andrisano V*. Advanced analytical methodologies in Alzheimer’s disease drug discovery. J. Pharm. Biomed. Anal. 2020, 178, 112899. DOI: 10.1016/j.jpba.2019.112899 (online: 2019-09-29).
24. De Simone A, Naldi M, Tedesco D, Milelli A, Bartolini M, Davani L, Widera D, Dallas ML, Andrisano V*. Investigating in vitro amyloid peptide 1–42 aggregation: Impact of higher molecular weight stable adducts. ACS Omega 2019, 4 (7), 12308–12318. DOI: 10.1021/acsomega.9b01531 (online: 2019-07-18).
23. Marchand CH, Fermani S*, Rossi J, Gurrieri L, Tedesco D, Henri J, Sparla F, Trost P, Lemaire SD, Zaffagnini M*. Structural and biochemical insights into the reactivity of thioredoxin h1 from Chlamydomonas reinhardtii. Antioxidants 2019, 8 (1), 10. DOI: 10.3390/antiox8010010 (online: 2019-01-01).
22. Lemaire SD, Tedesco D, Crozet P, Michelet L, Fermani S, Zaffagnini M*, Henri J*. Crystal structure of chloroplastic thioredoxin f2 from Chlamydomonas reinhardtii reveals distinct surface properties. Antioxidants 2018, 7 (12), 171. DOI: 10.3390/antiox7120171 (online: 2018-11-23).
21. Tramarin A, Tedesco D, Naldi M, Baldassarre M, Bertucci C, Bartolini M*. New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: Site-specific binding studies by induced CD spectroscopy. J. Pharm. Biomed. Anal. 2019, 162, 171–178. DOI: 10.1016/j.jpba.2018.09.022 (online: 2018-09-12).
20. Gandini A, Bartolini M, Tedesco D, Martínez-González L, Roca C, Campillo NE, Zaldivar-Diez J, Perez C, Zuccheri G, Miti A, Feoli A, Castellano S, Petralla S, Monti B, Rossi M, Moda F, Legname G, Martínez A, Bolognesi ML*. Tau-centric multi-target approach for Alzheimer’s disease: development of first-in-class glycogen synthase kinase 3β and tau-aggregation inhibitors. J. Med. Chem. 2018, 61 (17), 7640–7656. DOI: 10.1021/acs.jmedchem.8b00610 (online: 2018-08-04).
19. Andrisano V, Bartolini M, Tedesco D, Wainer IW*. Special Issue in honor of the retirement of Prof. Carlo Bertucci – Preface. J. Pharm. Biomed. Anal. 2017, 144, VI. DOI: [url=https://dx.doi.org/10.1016/S0731-7085(17)31895-2]10.1016/S0731-7085(17)31895-2[/url] (online: 2017-08-09).
18. Pasquini M, Fermani S*, Tedesco D, Sciabolini C, Crozet P, Naldi M, Henri J, Vothknecht U, Bertucci C, Lemaire SD, Zaffagnini M*, Francia F. Structural basis for the magnesium-dependent activation of transketolase from Chlamydomonas reinhardtii. BBA – Gen. Subjects 2017, 1861 (8), 2132–2145. DOI: 10.1016/j.bbagen.2017.05.021 (online: 2017-05-24).
17. Concilio G, Talotta C, Gaeta C, Neri P*, Monaco G*, Zanasi R, Tedesco D*, Bertucci C. Absolute configuration assignment of chiral resorcin[4]arenes from ECD spectra. J. Org. Chem. 2017, 82 (1), 202–210. DOI: 10.1021/acs.joc.6b02349 (online: 2016-12-07).
16. Bertucci C*, Tedesco D. Human serum albumin as chiral selector in enantioselective high-performance liquid chromatography. Curr. Med. Chem. 2017, 24 (8), 743–757. DOI: 10.2174/0929867324666161118115711 (online: 2016-11-18).
15. Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G*, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S. Development and pharmacological characterization of selective blockers of 2-arachidonoyl glycerol degradation with efficacy in rodent models of multiple sclerosis and pain. J. Med. Chem. 2016, 59 (6), 2612–2632. DOI: 10.1021/acs.jmedchem.5b01812 (online: 2016-02-18).
14. Fabini E, Fiori GML, Tedesco D, Lopes NP, Bertucci C*. Surface plasmon resonance and circular dichroism characterization of cucurbitacins binding to serum albumins for early pharmacokinetic profiling. J. Pharm. Biomed. Anal. 2016, 122, 166–172. DOI: 10.1016/j.jpba.2016.01.051 (online: 2016-01-27).
13. Tedesco D, Fabini E, Barbakadze V, Merlani M, Zanasi R, Chankvetadze B, Bertucci C*. Stopped-flow enantioselective HPLC-CD analysis and TD-DFT stereochemical characterization of methyl trans-3-(3,4-dimethoxyphenyl)glycidate. Chirality 2015, 27 (12), 914–918. DOI: 10.1002/chir.22539 (online: 2015-10-08).
12. Tedesco D, Bertucci C*. Induced circular dichroism as a tool to characterize the binding of drugs to carrier proteins: classic approaches and new trends. J. Pharm. Biomed. Anal. 2015, 113, 34–42. DOI: 10.1016/j.jpba.2015.02.024 (online: 2015-02-19).
11. Tedesco D, Zanasi R, Kirchner B, Bertucci C*. Short-range solvation effects on chiroptical properties: a TD-DFT and ab initio MD computational case study on austdiol. J. Phys. Chem. A 2014, 118 (50), 11751–11757. DOI: 10.1021/jp511428v (online: 2014-11-24).
10. Tedesco D, Pistolozzi M, Zanasi R, Bertucci C*. Characterization of the species-dependent ketoprofen/albumin binding modes by induced CD spectroscopy and TD-DFT calculations. J. Pharm. Biomed. Anal. 2015, 112, 176–180. DOI: 10.1016/j.jpba.2014.11.029 (online: 2014-11-22).
9. Bertucci C*, Tedesco D, Fabini E, Di Pietra AM, Rossi F, Garagnani M, Del Borrello E, Andrisano V. Determination of levamisole and tetramisole in seized cocaine samples by enantioselective high-performance liquid chromatography and circular dichroism detection. J. Chromatogr. A 2014, 1363, 150–154. DOI: 10.1016/j.chroma.2014.07.069 (online: 2014-07-29).
8. Sardella R, Carotti A, Manfroni G, Tedesco D, Martelli A, Bertucci C, Cecchetti V, Natalini B*. Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener. J. Chromatogr. A 2014, 1363, 162–168. DOI: 10.1016/j.chroma.2014.06.020 (online: 2014-06-12).
7. Andrioli WJ, Conti R, Araújo MJ, Zanasi R, Cavalcanti BC, Manfrim V, Toledo JS, Tedesco D, de Moraes MO, Pessoa C, Cruz AK, Bertucci C, Sabino J, Nanayakkara NPD, Pupo MT, Bastos JK*. Mycoleptones A–C and polyketides from the endophyte Mycoleptodiscus indicus. J. Nat. Prod. 2014, 77, 70–78. DOI: 10.1021/np4006822 (online: 2014-01-03).
6. Tedesco D, Zanasi R, Wainer IW, Bertucci C*. Stereochemical and conformational study on fenoterol by electronic circular dichroism and TD-DFT calculations. J. Pharm. Biomed. Anal. 2014, 91, 92–96. DOI: 10.1016/j.jpba.2013.12.018 (online: 2013-12-30).
5. Tedesco D, Di Pietra AM, Rossi F, Garagnani M, Del Borrello E, Bertucci C*, Andrisano V*. Determination of dextromethorphan and levomethorphan in seized heroin samples by enantioselective HPLC and electronic CD. J. Pharm. Biomed. Anal. 2013, 81–82, 76–79. DOI: 10.1016/j.jpba.2013.03.024 (online: 2013-04-06).
4. Dong F, Li J, Chankvetadze B, Cheng Y, Xu J, Liu X, Li Y, Chen X, Bertucci C, Tedesco D, Zanasi R, Zheng Y*. The chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity and environmental behavior in vegetables and soil. Environ. Sci. Technol. 2013, 47 (7), 3386–3394. DOI: 10.1021/es304982m (online: 2013-03-01).
3. Bertucci C*, Tedesco D. Advantages of electronic circular dichroism detection for the stereochemical analysis and characterization of drugs and natural products by liquid chromatography. J. Chromatogr. A 2012, 1269, 69–81. DOI: 10.1016/j.chroma.2012.09.046 (online: 2012-09-23).
2. Tedesco D, Zanasi R, Guerrini A, Bertucci C*. Conformational flexibility and absolute stereochemistry of (3R)-3-hydroxy-4-aryl-β-lactams investigated by chiroptical properties and TD-DFT calculations. Chirality 2012, 24 (9), 741–750. DOI: 10.1002/chir.22043 (online: 2012-04-29).
1. Bertucci C*, Pistolozzi M, Tedesco D, Zanasi R, Ruzziconi R, Di Pietra AM. Stereochemical characterization of fluorinated 2-(phenanthren-1-yl)propionic acids by enantioselective high performance liquid chromatography analysis and electronic circular dichroism detection. J. Chromatogr. A 2012, 1232, 128–133. DOI: 10.1016/j.chroma.2011.10.090 (online: 2011-11-09).

Other info: 

Orcid ID: 0000-0003-2585-7791
Scopus Author ID: 54409566200
WoS Researcher ID: L-1591-2015
LinkedIn: in/danieletedesco
Research Gate: Daniele_Tedesco
Google Scholar: Df6o34YAAAAJ