ASTROTALK

The ASTROTALK project aims to develop innovative technologies for the selective stimulation of astrocytes to better understand their role in brain function. It investigates the regulation of astrocytic calcium signaling, ion channels, and aquaporins using graphene oxide-based bioelectronic interfaces, microwave stimulation, entangled two-photon absorption (ETPA) laser pulses, and black phosphorus quantum nanodots. The project studies astrocyte–neuron interactions using primary neuron–astrocyte co-cultures, while adult neurospheres provide a physiologically relevant 3D model to evaluate glial function in a complex neural environment. Finally, it aims to determine how astrocyte modulation influences neuronal circuitry and to identify the underlying mechanisms. By establishing reliable astrocyte-targeting technologies, ASTROTALK seeks to provide new insights into astrocyte function and advance gliomodulation as a novel strategy for understanding and regulating brain function.