Photonics - Research Activities - Photoactive Materials for Biomedical Applications

Elisa Bandini, Massimo Benaglia, Ilse Manet, Francesco Manoli, Barbara Ventura

We investigate molecules that, upon interaction with light, generate useful chemical species and/or radicalic events and can be used as therapeutic agents. Our current research activity deals with: i) porphyrin and porphyrazin-based systems for photodynamic therapy and theranostic applications, and ii) naphthalene diimides as singlet oxygen sensitizers. We also explore different types of nanoparticles, some labelled with fluorophores, serving as carriers for singlet oxygen sensitizers and conventional drugs. Moreover, we synthesize RAFT controlled polymers to be also labelled with fluorescent probes. These polymers, that can be designed with self-assembling properties to form micelles, are studied as delivery and/or diagnostic agents.

Recent papers

    • V. Maffeis, M. Mamais, D. Markovitsi, K. Mavreas, F. Monti, T. Gustavsson, E. D. Chrysina, T.Gimisis and A. Venturini*
      “Multiscale time-resolved fluorescence study of a glycogen phosphorylase inhibitor combined with quantum chemistry calculations”
      Phys. Chem. Chem. Phys., 2019, 21, 7685—7696
    • F. Doria, E.Salvati, L. Pompili, V. Pirota, C.D'Angelo, F. Manoli, M. Nadai, S.N. Richter, A. Biroccio, I. Manet, M. Freccero
      “Dyads of G‐Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration.”
      Chem. Eur. J. 2019, 25, 11085–11097
    • J. Schmitt, S. Jenni, A. Sour, V. Heitz, F. Bolze, A. Pallier, C. S. Bonnet, É. Tóth, B. Ventura
      "A Porphyrin Dimer-GdDOTA Conjugate as a Theranostic Agent for One- and Two-Photon Photodynamic Therapy and MRI"
      Bioconjugate Chem. 2018, 29, 3726-3738
    • J.Wankar, F. Bonvicini, G. Benkovics, V. Marassi, M. Malanga, E. Fenyvesi, G.A. Gentilomi, P. Reschiglian, B. Roda and I. Manet
      “Widening the Therapeutic Perspectives of Clofazimine by Its Loading in Sulfobutylether β-Cyclodextrin Nanocarriers: Nanomolar IC50 Values against MDR S. epidermidis”
      Mol. Pharmaceutics, 2018, 15, 3823-3836
    • M. Mamais, A.Degli Esposti, V. Kouloumoundra, T. Gustavsson, F. Monti, A. Venturini, E. D. Chrysina, D.Markovitsi and T. Gimisis
      “A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site”
      Chem. Eur. J. 2017, 23, 8800 – 8805
    • F. Sciscione, F.Manoli, E. Viola, J. Wankar, C. Ercolani, M.P. Donzello, and I. Manet
      “Photoactivity of New Octacationic Magnesium(II) and Zinc(II)Porphyrazines in a Water Solution and G-Quadruplex Binding Ability of Differently Sized Zinc(II) Porphyrazines”
      Inorg. Chem., 2017, 56, 12795-12808
    • S. Valetti, J. Wankar, M.B. Ericson, A. Feiler, and I. Manet
      “Mesoporous silica particles as a lipophilic drug vehicle investigated by fluorescence lifetime imaging”
      J. Mater. Chem. B, 2017, 5, 3201-3211
    • Sour, S. Jenni, A. Ortí-Suárez, J. Schmitt, V. Heitz, F. Bolze, P. Loureiro de Sousa, C. Po, C. S. Bonnet, A. Pallier, É. Tóth, B. Ventura
      “Four Gadolinium(III) Complexes Appended to a Porphyrin: A Water-Soluble Molecular Theranostic Agent with Remarkable Relaxivity Suited for MRI Tracking of the Photosensitizer”
      Inorg. Chem. 2016, 55, 4545−4554
    • J. Schmitt, V Heitz, A. Sour, F. Bolze, P. Kessler, L. Flamigni, B. Ventura, C. S. Bonnet, É. Tóth
      “A Theranostic Agent Combining a Two-Photon-Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection”
      Chem. Eur. J. 2016, 22, 2775-2786
    • E. Salvati, F. Doria, F. Manoli, C. D'Angelo, A. Biroccio,M. Freccero, and I. Manet
      “A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications”
      Org. Biomol. Chem. 2016, 14, 7238-7249
    • J. Schmitt, V. Heitz, A. Sour, F. Bolze, H. Ftouni, J.-F. Nicoud, L. Flamigni, B. Ventura
      “Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy”
      Angew. Chem. Int. Ed., 2015, 54, 169-173
    • F. Di Maria, L. Blasi, A. Quarta, G. Bergamini, G. Barbarella, L. Giorgini, M. Benaglia
      “New biocompatible polymeric micelles designed for efficient intracellular uptake and delivery”
      J. Mater. Chem. B, 2015, 3, 8963-8972
    • Fraix, N. Kandoth, I. Manet,* V. Cardile, A. C. E. Graziano, R. Gref and S. Sortino,
      “An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers”,
      Chem. Commun., 2013, 49, 4459-4461