Ferreri Carla

Senior Researcher
Office telephone : 
+39 051 639 8289
Isof 12
Office number: 
Research Unit: 

Laurea degree in Medicinal Chemistry and a post-graduate specialty in Hospital Pharmacy, started working in the field of organic synthesis joining in 1983 the group of Prof. E. Wenkert at the University of San Diego, California. In 1984 she was appointed as permanent staff (researcher; assistant professor) in the Organic and Biological Chemistry Department at the University of Napoli until 2001, when she moved to the Consiglio Nazionale delle Ricerche, Bologna. At present, she is Senior Researcher at ISOF, CNR, Bologna leading the research group BioFreeRadicals. Her present research interests are in the field of free radical chemistry, biomimetic chemistry of stress conditions affecting the main biological molecules (lipids, DNA, proteins), membrane lipidomics, biomarker discovery and novel nanotechnology development with application in life sciences, nutrition and molecular medicine. She is responsible of the CNR research project on lipidomics and nutraceuticals, founder of two spin-off companies in Italy and Greece, consultant for AZTI, a Spanish organization in the TechnoPark of Bilbao on nutra-innovation, and author of more than 150 papers, 2 books and 3 patents.

Laureata in farmacia e post-graduata in Farmacia Ospedaliera, ha iniziato la sua attività in chimica farmaceutica e chimica organica sintetica, e nel 1983 ha svolto ricerca con il gruppo del prof. E. Wenkert all’Università di California San Diego. Nel 1984 ha vinto il concorso per una posizione permanente di ricercatore all’Università Federico II di Napoli presso il Dipartimento di Chimica Organica e Biologica. Nel 2001 è divenuta Ricercatore presso l’istituto ISOF del Consiglio Nazionale delle Ricerche di Bologna, dove attualmente è Primo Ricercatore alla guida del gruppo BioFreeRadicals. I suoi interessi di ricerca attuali sono nel campo dei radicali liberi, le condizioni di stress e l’ambiente di simulazione biomimetico riguardante le principali molecole biologiche (lipidi, DNA e proteine), la lipidomica di membrana, lo sviluppo di biomarcatori e nuove nanotecnologie, con applicazione alle scienze della vita, nutrizione e medicina molecolare. E’ responsabile del progetto CNR su lipidomica e nutraceutica, fondatrice di due aziende spin-off in Italia e Grecia, consulente ddell’organizzazione spagnola AZTI nel Parco Tecnologico di Bilbao per innovazione nel campo della nutrizione, autrice di più di 150 pubblicazioni, 2 libri e 3 brevetti.


Pubblicazioni ultimi 3 anni - Last 3 years' publications
112. Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect of different nutritional lipid patterns
Aoun, M; Feillet-Coudray, C.; Fouret, G.; Chabi, B. Crouzier, D.; Ferreri, C.; Chatgilialoglu, C.; Cabello, C.; Cristol, J. P.; Carbonneau, M.-A.; Coudray, C. Br. J. Nutr.2012, 107, 647-59

113. Jiang, D.; Barata-Vallejo, S.; Golding, B. T.; Ferreri, C.; Chatgilialoglu, C. Revisiting the reaction of hydroxyl radicals with 1,2-diols in water. Org. Biomol. Chem 2012, 10, 1102-1107

114. Ferreri, C.; Grabovskiy, S.; Aoun, M.; Melchiorre, M.; Kabal’nova, N.; Feillet-Coudray, C.; Fouret, G.; Coudray, C.; Chatgilialoglu, C. Mono-trans eicosapentaenoic acid isomer library: a dual synthetic strategy and follow-up of rats fed deodorized fish oil diets. Chem. Res. Toxicol 2012, 25 , 687–694

115. Audette-Stuart, M., Ferreri, C.., Festarini, A. and Carr, J. Fatty acid composition of muscle tissue measured in amphibians living in radiologically contaminated and non-contaminated environments. Radiat. Res. 2012, 178(3):173-181.
116. Souabni, H.; Thoma, V.; Bizouarn, T.; Chatgilialoglu, C.; Siafaka-Kapadai, A.; Baciou, L.; Ferreri, C.; Houée-Lévin, C.; Ostuni, M.A. trans arachidonic acid isomers inhibits NADPH-oxidase activity by direct interaction with enzyme components, BBA Biomembranes, 2012, 1818, 2314-2324.

117. Krogager, T.P., , Nielsen, L. V., Bak, S., Young, C., Ferreri, C., Jensen, O.N., , Højrup, P., Thoma, V., Thøgersen, I. B, Enghild, J.J. Identification of a potential biomarker panel for the intake of the
common dietary trans fat elaidic acid (transΔ9-C18:1). J. Prot. 2012, 75, 2685-2696

118. C. Chatgilialoglu, C. Ferreri, A. Masi, M. Melchiorre, A. Sansone, M. A. Terzidis, A. Torreggiani, Biomimetic Models of Radical Stress and Related Biomarkers. Chimia, 2012, 66, 368–371.

119. C. Chatgilialoglu, C. Ferreri,. The role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools. Expert Rev. Mol Diagn 2012 12: 767–780

120. C. Chatgilialoglu, C. Ferreri. Nutrilipidomics: a tool for personalized health. Glycomics Lipidomics, 2012, 2, e109: doi: 10.4172/2153-0637.1000e109

121. A. Bolognesi, A, Chatgilialoglu, L. Polito, C. Ferreri, Membrane lipidome reorganization correlates with the fate of neuroblastoma cells supplemented with fatty acids, PLOSONE, 2013;8(2):e55537. doi: 10.1371/journal.pone.0055537.

122. L. Vendel Nielsen, T. P. Krogager, C. Young, C. Ferreri, C. Chatgilialoglu, O. Nørregaard Jensen, J. J. Enghild. Effects of elaidic acid on HepG2 lipid metabolism, investigated by an integrated approach of lipidomics, transcriptomics and proteomics. PLOSONE, 2013, 8(9): e74283. doi:10.1371/journal.pone.0074283

123. A. Ghezzo; P. Visconti; P. M. Abruzzo; A. Bolotta; C. Ferreri; G. Gobbi; G. Malisardi; S. Manfredini; M. Marini, E. Pipitone; L. Nanetti; F. Raffaelli; F. Resca; A. Vignini; L. Mazzanti. Oxidative stress and erythrocyte membrane alterations in children with autism: correlation with clinical features. PLOSONE, 2013, 8(6): e66418. Doi:10.1371/journal.pone.00666418

124. Cohen. G., Riahi. Y., Sunda. V., Deplano. S., Chatgilialoglu. C., Ferreri. C., Kaiser. N., Sasson. S. Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes. Free Radical Biol. Med. 2013, 65, 978-987.

125. Sansone, A., Melchiorre, M., Chatgilialoglu, C., Ferreri C. Hexadecenoic Fatty Acid Isomers: A Chemical Biology Approach for Human Plasma Biomarker Development. Chem Res. Toxicol. 2013, 26, 1703-1709

126. G. S. Verebes, M. Melchiorre, A. Garcia-leis, C. Ferreri, C. Marzetti, A. Torreggiani , Hyperspectral enhanced dark field microscopy for imaging blood cells. J. Biophotonics 2013 , 6 , 960–967.

127. Chatgilialoglu, C., Ferreri, C., Masi, A., Melchiorre, M., Sansone, A., Terzidis, M. A., et al. Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development. J. Vis. Exp. 2013, 74, e50379, doi:10.3791/50379).

128. Torreggiani, A, Chatgilialoglu, C., Ferreri C., Melchiorre M., Atrian, S., Capdevila, M. Non-enzymatic modifications in metallothioneins connected to lipid membrane damages: Structural and biomimetic studies under reductive radical stress. J. Prot., 2013, 92, SI204-215.

129. C. Chatgilialoglu, C. Ferreri, M. Melchiorre, A. Sansone, A. Torreggiani. Lipid Geometrical Isomerism: From Chemistry to Biology and Diagnostics. Chem Rev. 2014, 114, 255-284.

130. Chatgilialoglu, C., Ferreri, C., Masi, A., Sansone, A., Terzidis, M. A., Tsakos , M. A problem solving approach for the diastereoselective synthesis of (5’S)- and (5’R)-5’,8-cyclopurine lesions. Org. Chem. Front. 2014, 1, 698-702.

131. Chatgilialoglu, C; Ferreri, C; Lykakis, I N.; Mihaljevic Branka. Biomimetic Thiyl Radical Chemistry by gamma-Irradiation of Micelles and Vesicles Containing Unsaturated Fatty Acids. Isr. J. Chem. 2014, 54,

132. Bianchi, A. R., Ruggieo, S., Formisano, C., Galloro, G., de Maio, A., Ferreri, C., Faraone Mennella, M. R. Auto-modification of poly(ADP-ribose) polymerase and membrane lipid composition as diagnostic tools to measure the physiopathological state of the cell. J. Microb. Biochem. Techn. 2014, 6, 223-227.

133. I Martini, E. G. Di Domenico, R. Scala, F. Caruso, C. Ferreri, F. M. Ubaldi, A. Lenzi and H. Valensise. Optimization of the viability of stem cells derived from umbilical cord blood after maternal supplementation with DHA during the second or third trimester of pregnancy: study protocol for a randomized controlled trial, Trials 2014, 15, article n. 164 MS: 1728135010107257

134. Riezzo. G., Ferreri, C., Russo, O., Martulli, M., D’attoma, B., Russo, F. Lipidomic analysis of fatty acids in erythrocytes from celiac patients before and after a gluten free diet a comparison with healthy subjects. Br. J. Nutr. 2014, 112, 1787-1796.

135. Cort, A., Ozben, T., Sansone, A., Barata-Vallejo, S., Chatgilialoglu, C., Ferreri, C. Bleomycin-induced trans lipid formation in cell membranes and in liposome models. Org. Biomol. Chem. 2015, 13, 1100-1105.

136. Lykakis, I. N., Ferreri, C., Chatgilialoglu, C. Biomimetic Chemistry on the protection of cis phospholipids from the thiyl radical isomerization by common antioxidants, Arkivoc 2015, 140-153; doi: 10.3998/ark.5550190.p008.984

137. Melchiorre, M., Ferreri, C., Tinti, A., Chatgilialoglu, C., Torreggiani, A. A promising Raman spectroscopy technique for the investigation of trans and cis cholesteryl ester isomers in biological samples. Appl. Spectroscopy 2015, 69, 613-622.

138. Cohen, G., Shamni, O., Avrahami, Y, Cohen, O. Broner, E. C., Filippov-Levy, N., Chatgilialoglu, C., Ferreri, C., Kaiser, N., Sasson, S. Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation, Diabetologia 2015, 58, 1333-1343.

139. Fouret, G., Tolika, E., Lecomte, J., Bomafos, B., Aoun, M., Murphy, M. P., Ferreri, C., Chatgilialoglu, C., Dubreucq, E., Coudray, C., Feillet-Coudray, C. The mitochondrial-targeted antioxidant, MitoQ, increases liver mitochondrial cardiolipin content in obesogenic diet-fed rats. BBA Bioenergetics, 2015, 1847, 1025-1035

140. Terzidis, M. A., Ferreri, C., Chatgilialoglu, C. Radiation-induced formation of purine lesions in single and double stranded DNA: revised quantification. Front. Chem. 2015, 3:18; doi: 10.3389/fchem.2015.00018.

141. Chatgilialoglu, C., Ferreri, C., Matyjaszewski, K. Radicals and Dormant Species in Biology and Polymer Chemistry. ChemPlusChem. 2015, doi: 10.1002/cplu.201500271


C. Ferreri, C. Chatgilialoglu, Membrana cellulare e lipidomica: la salute dalla medicina molecolare, Edizioni CNR: Roma, prima edizione 2011 ; ISBN: 9788880801306; seconda edizione 2015.

C. Ferreri, C. Chatgilialoglu. Membrane Lipidomics for Personalized Health, Wiley, 2015.