Sansone Anna

Anna Sansone graduated in Pharmacy in 2004 at Sapienza University of Rome and obtained a Ph.D. in Pharmaceutical Sciences (Medicinal Chemistry) in 2008, focusing on the design, synthesis and biological evaluation of peptides and pseudopeptides targeting β-amyloid, endomorphin analogues and chemotactic agents. From 2008 to 2011, she held research grants at CNR, the Cenci Bolognetti Foundation and the University of Padova, working on nucleic acids, antiviral peptides and nanoenzyme inhibitors. Since 2011, she has been a permanent researcher at ISOF-CNR.

Development of chemical-analytical methodologies for lipidomic applications. Identification of lipid biomarkers associated with diseases. Synthesis and characterization of trans lipid libraries. Design of liposomes and proteo-liposomes as nanocarriers for drug delivery and the formulation of bioactive molecules, as biomimetic cell membrane models for studying radical mechanisms and antioxidant or enzymatic activity assays, and as colorimetric biosensors. Characterization of nutraceuticals based on fatty acids and antioxidants. Synthesis, characterization, and evaluation of peptidic and pseudopeptidic bioactive molecules.

Methods for applications in lipidomics • Lipid biomarkers • Fatty acids: positional and geometric isomers (cis-trans) • Liposomes and applications • Peptides and peptidomimetics

PE5 Synthetic Chemistry and Materials
PE4 Physical and Analytical Chemical Sciences
LS2 Integrative Biology: from Genes and Genomes to Systems

Synthesis and characterization of trans lipid libraries, solid-phase peptide synthesis, liposomal design and development; instrumental skills: GC, GC-MS, HPLC-MS, UV-Vis, DLS.