Ferroni Claudia

Position: 
Researcher
e-mail: 
Office telephone : 
+39 051 639 8286
Building: 
Isof 12
Floor: 
1
Office number: 
322
Research Unit: 
ChemNanoCare
Group: 
Researchers
Biography: 
EDUCATION

2009-2012 Ph.D. degree in Pharmaceutical Sciences, at the University of Bologna. Title: “Research, synthesis and characterization of compounds with antitumoral activity”. Advisor: Prof. Alessandra Bisi.
2008 License to practice pharmacy, at the University of Bologna
1999-2007 Bachelor Degree in Pharmaceutical Chemistry and Technology at the University of Bologna, grade 110/110 cum Laude. Title: ”Design and Synthesis of AP2238 derivatives: multi-target strategy for treatment of AD”. Advisor: Prof. Angela Rampa.
1999 Linguistic diploma, grade 100/100 at the Ist. Magistrale Statale-Indirizzo linguistico, Rieti.

RESEARCH EXPERIENCE

Since August 2018: Postdoctoral Research at ISOF-CNR.
2017-2018: Postdoctoral Researcher at ISOF-CNR ChemNanoCare Unit. Supervisor: Dr. Greta Varchi. "Albumin-based multimodal cancer therapy: a light triggered implemented approach”
2015-2017: Postdoctoral Researcher at ISOF-CNR Biochemoinformatics Unit. Supervisor: Dr. Alberto Del Rio. “Proof of concept studies of SIRT6 inhibitors for treating type II diabetes"
2013-2015: Postdoctoral Researcher at the National Research Council (ISOF-CNR) Research Supervisor: Dr. Greta Varchi. Synthesis of small molecules with biological activity and from June 2013 till May 2014 Scientific Responsible of research agreements between CNR-ISOF and Aczon s.r.l. about research, synthesis and characterization of fluorescent dyes.
2012-2013: Researcher Co.co.pro for Aczon s.r.l. at MISO Laboratory (research, synthesis and characterization of fluorescent dyes).
2009-2010 Occasional Collaboration with Flat s.r.l. for determination of total microbial surface and air of operating rooms and kitchens
2008-2012 Visiting Scientist at ISOF-CNR (synthesis and characterization of antitumoral compounds).
2007-2008 Fellowship Winner for Endura s.p.a. (development of a new class of insecticides).

Publications: 
  1. Pistolozzi M, Varchi G, Degli Esposti A, Guerrini A, Sotgiu G, Ballestri G, Ferroni C, Venturini A, Bertucci C. Camptothecin and thiocamptothecin: the role of sulfur in shifting the hydrolysis equilibrium towards the closed lactone form. ChemMedChem2011, 6, 1706-1714.
  2. Duchi S, Sotgiu G, Lucarelli E, Ballestri M, Dozza B, Santi S, Guerrini A, Dambruoso P, Giannini S, Donati D, Ferroni C, Varchi G. Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: effective photoinduced in vitro killing of osteosarcoma. J. Control Release 2013, 168, 225-237.
  3. Pepe A, Ferroni C, Kim YS, Guerrini A, Trepel JB, Malhotra SV, Varchi G. Synthesis and the biological evaluation of triazole-based novel antiandrogens. Abstracts of Papers of the American Chemical Society 2013, 245, 1.
  4. Guerrini A, Tesei A, Ferroni C, Paganelli G, Zamagni A, Carloni S, Di Donato M, Castoria G, Leonetti C, Porru M, De Cesare M, Zaffaroni N, Beretta LG, Del Rio A, Varchi G. A new avenue towards androgen receptor pan-antagonists: C2-steric hindered substitution of hydroxy-propanamides. J. Med. Chem.2014, 57 (17), 7263–7279.
  5. Ferroni C, Bassetti L, Borzatta V, Capparella E, Gobbi C, Guerrini A, Varchi G. Polyenylcyclopropane carboxylic esters with high insecticidal activity. Pest Manag. Sci. 2015, 71 (5), 728-736.
  6. Ferroni C, Chini MG, Cantone V, Dambruoso P, Varchi G, Pepe A, Fischer K, Pergola C, Werz O, Bruno I, Riccio R, Bifulco G. Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitor. MedChemComm.2015, 6, 75-79.
  7. Dambruoso P, Ballestri M, Ferroni C, Guerrini A, Sotgiu G, Varchi G, Massi A. TPPS supported on core-shell PMMA nanoparticles: the development of continuous-flow membrane- mediated electrocoagulation as photocatalyst processing method in aqueous media. Green Chem.2015, 17, 1907-1917.
  8. Rapozzi V, Ragno D, Guerrini A, Ferroni C, Della Pietra E, Cesselli D, Castoria G, Di Donato M, Saracino E, Benfenati V, Varchi G. Androgen receptor targeted conjugate for bimodal photodynamic therapy of prostate cancer in vitro. Bioconjugate Chem. 2015, 26(8), 1662-1671.
  9. Sociali G, Galeno L, Parenti MD, Grozio A, Bauer I, Passalacqua M, Boero S, Donadini A, Millo E, Bellotti M, Sturla L, Damonte P, Puddu A, Ferroni C, Varchi G, Franceschi C, Ballestrero A, Poggi A, Bruzzone S, Nencioni A, Del Rio A. Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. Eur. J. Med. Chem. 2015, 102, 530-9.
  10. Aluigi A, Sotgiu G, Dambruoso P, Guerrini A, Ballestri M., Ferroni C, Varchi G. Chapter 9. Eco-Friendly Electrospun Membranes made of Biodegradable Polymers for Wastewater Treatment. Electrospinning for Advanced Energy and Environmental Applications. Edited by Cavaliere, 2015, 219-242.
  11. Aluigi A, Sotgiu G, Ferroni C, Duchi S, Lucarelli E, Martini C,Posati T, Guerrini A, Ballestri M, Corticelli F, Varchi G. Chlorin e6 keratin nanoparticles for photodynamic anticancer therapy. RSC Adv. 2016, 6, 33910-33918.
  12. Ferroni C, Sotgiu G, Sagnella A, Varchi G, Guerrini A, Giuri D, Polo E, Orlandi VT; Marras E, Gariboldi M, Monti E, Aluigi A. Wool keratin 3D scaffolds with light-triggered antimicrobial activity. Biomacromolecules,2016, 17(9), 2882-2890.
  13. Posati T, Sotgiu G, Varchi G, Ferroni C, Zamboni R, Corticelli F, Puglia D, Torre L, Terenzi A, Aluigi A. Developing keratin sponges with tunable morphologies and controlled antioxidant properties induced by doping with polydopamine (PDA) nanoparticles. Materials & Design Journal, 2016, 110, 475-484.
  14. Rapozzi V, Ferroni C, Varchi G. Highlights of the Fifth International Workshop on Nitric Oxide and Cancer. Crit. Rev. Oncog. 2016, 21(5-6), 309–324.
  15. Rapozzi V, Varchi G, Della Pietra E, Ferroni C, Xodo LE. A photodynamic bifunctional conjugate for prostate cancer: an in vitro mechanistic study. Investigational New Drugs, 2017, 35(1), 115-123.
  16. Ferroni C, Pepe A, Kim YS, Lee S, Guerrini, Parenti MD, Tesei A, Zamagni A, Cortesi M, Zaffaroni N, De Cesare M, Beretta GL, Trepel JB, Malhotra SV, Varchi G.1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment, J. Med. Chem., 2017, 60 (7), 3082-3093.
  17. Aluigi A, Ballestri M, Guerrini A, Sotgiu G, Ferroni C, Corticelli F, Gariboldi MB, Monti E, Varchi G. Organic solvent-free preparation of keratin nanoparticles as doxorubicin carriers for antitumor activity, Materials Science & Engineering C, 2018, 90, 476-484.
  18. Posati T, Ferroni C, Aluigi A, Guerrini A, Rossi F, Tatini F, Ratto F, Marras E, Gariboldi MB, Sagnella A, Ruani G, Zamboni R, Varchi G, Sotgiu G. Mild and Effective Polymerization of Dopamine on Keratin Films for Innovative Photoactivable and Biocompatible Coated Materials, Macromol. Mater. Eng., 2018, 1700653.
  19. Foglietta F, Varchi G, Muraro MG, Ballestri M, Guerrini A, Ferroni C, Aluigi A, Sotgiu G, Spagnoli GC. Anticancer activity of paclitaxel-loaded keratin nanoparticles in bi-dimensional and perfused tri-dimensional breast cancer models, Int. J. Nanomedicine, in press
  20. Posati T, Giuri D, Nocchetti M, Sagnella A, Gariboldi M, Ferroni C, Sotgiu G, Varchi G, Zamboni R, Aluigi A. Keratin-Hydrotalcites hybrid films for drug delivery applications. Eur. Polym. J.,2018, 105, 177-185.
  21. Ballestri M, Caruso E, Guerrini A, Ferroni C, Banfi S, Gariboldi M, Monti E, Sotgiu G, Varchi G. Core-shell poly-methyl methacrylate nanoparticles covalently functionalized with a non-symmetric porphyrin for anticancer photodynamic therapy. J. Photochem. Photobiol. B, 2018, doi: 10.1016/j.jphotobiol.2018.07.013. Pubblicato il 25 Luglio 2018.
  22. Ferroni C, Varchi G. Non-Steroidal Androgen Receptor Antagonists and Prostate Cancer: A Survey on Chemical Structures Binding This Fast-Mutating Target. Curr. Med. Chem., just accepted